Process of making hemoglobin preparations.



of wine, especially Malaga wine.

i\To. 736,256:

- 1 UNITED STATES Patented August 11, 1903.

PATENT FFICE.

PROCESS OF MAKING HEIVIO GLOBIN PREPARATIONS.

SPECIFICATION forming part of Letters Patent No. 736,250, dated August11, 1903.

l Application filed September 3, 1902. Serial No. 122.001. (Nospecimens.)

To 60% whom it may concern.-

Be it known that I, Farnnnron HANSSEN, a

subject of the Emperor of Germany, residing at Altona-on-the-Elbe, intheEmpire of Germany, have invented certain new and useful Improvementsin Processes of Producing Medicinal Preparations of Hemoglobin, of whichthe following is a specification.

The hemoglobin of the blood and blood free from fibrin have already beenutilized for producing blood-formingliquid preparations. As the bloodand the hemoglobin easily become decomposed and, moreover, have adecidedly unpleasant taste, attempts have been made to preserve theliquid preparations made therefrom by adding thereto a somewhatconsiderable quantity of glycerin and toremove the taste of blood by theaddition Glycerin, however, is not a neutral substance. It isindigestible and irritates the mucous memacid.

oglobin being converted into carbonated hemoglobin by the introductionof carbonic I have found that hemoglobin can be more easily preservedfrom decomposition when combined with carbonic acid and that the tasteof blood'belonging thereto is considerably lessened and can be entirelyremoved by the suitable addition of aromatic substances.

The process consists generally in mixing hemoglobin of any kind withcarbonic acid. In such case the carbonic acid combines with thehemoglobin, and the solution is mixed,

for instance, with a spirituous extract of' Blood free of fibrin mayalso be.

completely separated from the serum and the hemoglobin thus obtained bedissolved in water or a liquid containing water and then be mixed withthe carbonic acid.

It is not possible to enumerate all the different ways of carrying outthe process. It may, however, be especially observed that thepreparation can be mixed with milk. It is, in fact, very advisable toadminister the preparation mixed with milk. This mixture with milk is ofa color resembling chocolate.

If suitable spices be used, especially vanilla in the form of aspirituous extract, a beverage is obtained which has exactly the colorand taste of chocolate. It is obvious that this is an importantadvantage in medicinal preparations compared with the blood preparationshitherto known, as the value of a medicinal preparation depends not onlyupon its effect,butalso largely upon the particularflavor whichfacilitates its being taken.

In this process diluted as well as concentrated solutions of hemoglobinmay be employed.

The process may also be carried out so that the excess carbonic acid isallowed to evaporate or any excess of carbonic acid may be allowed toremain in the preparation.

The combination of the carbonic acid with the hemoglobin may be effectedby adding carbonates or bicarbonates to the mixture and then setting thecarbonic acid free by adding a suitable acid, such as tartaric, citric,or other edible acid. In connection herewith a certain portion of thecarbonate may in certain cases be left undecomposed.

Having now particularly described and ascertained the nature of my saidinvention and in what manner the same is to be performed, I declare thatwhat I claim is- The process herein described for producing medicinalpreparations of hemoglobin which consists in mixing solutions ofhemoglobin with carbonates and then adding an acid which will set freethe carbonic acid, substantially as set forth.

In witness whereof I have hereunto set'my hand in presence of twoWitnesses.

FRIEDRICH HANSSEN.

Witnesses:

E. H. L. MUMMENHOFF, OTTO W. HELLMRIOH.

